Ashwagandha
Ashwagandha (Withania somnifera) is an adaptogenic herb traditionally used for stress. Several small randomized trials report modest reductions in perceived stress, anxiety, and cortisol, with some signal for improved sleep, though studies are short, small, and industry-funded. It is generally well tolerated, but rare cases of liver injury have been reported and it may interact with thyroid and sedative medications.
Too little may be associated with
Less stress relief.
Too much may be associated with
Drowsiness, GI upset; thyroid and liver cautions.
Informational only โ not medical advice.
Benefits
Adaptogenic herb studied for lowering perceived stress and cortisol, improving sleep quality, and supporting exercise recovery.
Risks
Can cause drowsiness or GI upset and may alter thyroid hormone levels; rare liver injury has been reported. Avoid in pregnancy and combine cautiously with sedatives or thyroid medication.
Informational only โ not medical advice.
Body systems
Organs
Functions
- Sleep Regulationย (โ)
- Stress Responseย (โ)
Hormones
Neurotransmitters
Related
Where to buy
Popular Ashwagandha products on Amazon. Not medical advice โ talk to a clinician before starting a supplement.
As an Amazon Associate, Neurotransmission earns from qualifying purchases.
Books (1)
Research (8)
- Ashwagandha Root Extract Mitigates Fibromyalgia-like Symptoms via Neurochemical and Histological Modulation in Mice Hasanyn et al. (2025) Full text โ PubMed โ
- Health-Related Messages About Herbs, Spices, and Other Botanicals Appearing in Print Issues and Websites of Legacy Media: Content Analysis and Evaluation Gaba et al. (2024) Full text โ PubMed โ
- A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study Majeed et al. (2024) Full text โ PubMed โ
- A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study Majeed et al. (2023) Full text โ PubMed โ
- Interventions for generalized anxiety disorder Byrne (2023) Full text โ PubMed โ
- Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce Sarris et al. (2022) PubMed โ
- Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo Experimental Models Murthy et al. (2022) Full text โ PubMed โ
- GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence Savage et al. (2018) Full text โ PubMed โ
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