Leptin
The satiety hormone secreted by fat cells that signals energy sufficiency to the brain, suppressing appetite. Chronically high levels can blunt the brain's response (leptin resistance).
Too little may be associated with
Intense hunger and low energy expenditure (rare congenital deficiency).
Too much may be associated with
Leptin resistance, in which high levels no longer curb appetite (common in obesity).
Informational only — not medical advice.
Organ systems
Stimuli that influence it
Behaviors
Functions
Dysfunctions
Books (2)
Research (11)
- Hypothalamic Dysfunction Casipit et al. (2026) PubMed ↗
- Molecular pathways in placental-fetal development and disruption Zhao et al. (2024) Full text ↗ PubMed ↗
- Obesity as a Neuroendocrine Disorder Ferreira-Hermosillo et al. (2023) Full text ↗ PubMed ↗
- Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors Alizadeh (2022) Full text ↗ PubMed ↗
- Isocaloric Fructose Restriction Reduces Serum d-Lactate Concentration in Children With Obesity and Metabolic Syndrome Robert (2019) Full text ↗ PubMed ↗
- Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial David (2018) Full text ↗ PubMed ↗
- Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome Robert (2016) Full text ↗ PubMed ↗
- Dietary treatment of nonalcoholic steatohepatitis Robert (2013) Full text ↗ PubMed ↗
- Fructose: metabolic, hedonic, and societal parallels with ethanol Robert (2010) Full text ↗ PubMed ↗
- The 'skinny' on childhood obesity: how our western environment starves kids' brains Robert (2006) Full text ↗ PubMed ↗
- [Ghrelin: beyond hunger regulation] Milke (2005) PubMed ↗
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