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Creatine

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substance Score Unrated 1 rating— needs ≥ 3 ratings C4H9N3O2 Also on Neurotransmission ↗
Anti-aging
⤢ 3D

Creatine is among the most studied and effective supplements for increasing muscle strength, power, and lean mass, with a strong safety record. Emerging research suggests it may also modestly support cognition and mood, with the clearest effects under stress such as sleep deprivation and in people with low dietary intake (e.g., vegetarians). Cognitive benefits are promising but less established than the physical ones.

Too little may be associated with

Lower energy reserves, especially in vegetarians.

Too much may be associated with

Water retention; safe for most.

Informational only — not medical advice.

Benefits

One of the best-evidenced supplements: increases strength, power, and lean mass, with growing interest in cognitive and neuroprotective effects.

Risks

Very safe at recommended doses—may cause water-weight gain and occasional GI upset. Stay hydrated, and use caution with pre-existing kidney disease.

Informational only — not medical advice.

Body systems

Organs

Amino acids

Functions

Neurotransmitters

Where to buy

Popular Creatine products on Amazon. Not medical advice — talk to a clinician before starting a supplement.

As an Amazon Associate, Neurotransmission earns from qualifying purchases.

Books (4)

Podcasts

Research (14)

Links

Community

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  • @henry· Risk 1/10 · Benefit 10/10 0