Glutathione — Homeostation

substance Score Unrated 0 ratings— needs ≥ 3 ratings C₁₀H₁₇N₃O₆S

The body’s master antioxidant tripeptide (cysteine, glutamate, glycine), taken as a supplement.

Benefits

The body’s master antioxidant; supplements and precursors are explored for oxidative-stress and liver support.

Risks

Oral bioavailability is limited, and unregulated IV skin-whitening use is risky. Generally well tolerated at supplement doses, but long-term data are limited.

Informational only — not medical advice.

Body systems

Organs

Amino acids

Where to buy

Popular Glutathione products on Amazon. Not medical advice — talk to a clinician before starting a supplement.

As an Amazon Associate, Neurotransmission earns from qualifying purchases.

Research (16)

Glycine as a conditionally essential amino acid and its relationship to l-serine Holeček (2025) Full text ↗ PubMed ↗
Exploring the Safety and Efficacy of Glutathione Supplementation for Skin Lightening: A Narrative Review Alzahrani et al. (2025) PubMed ↗
Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome Hillis et al. (2024) Full text ↗ PubMed ↗
Intermittent fasting alerts neurotransmitters and oxidant/antioxidant status in the brain of rats Abdel-Rahman et al. (2024) Full text ↗ PubMed ↗
M2 Microglia-Derived Exosomes Protect Against Glutamate-Induced HT22 Cell Injury via Exosomal miR-124-3p Zhang et al. (2024) Full text ↗ PubMed ↗
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis Woo et al. (2024) Full text ↗ PubMed ↗
A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study Majeed et al. (2023) Full text ↗ PubMed ↗
Causes and Clinical Sequelae of Riboflavin Deficiency McNulty et al. (2023) PubMed ↗
Glycine and aging: Evidence and mechanisms Johnson et al. (2023) PubMed ↗
Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy Essawy et al. (2022) Full text ↗ PubMed ↗
Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives Garcia et al. (2021) PubMed ↗
Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice Wang et al. (2021) Full text ↗ PubMed ↗
Insulin resistance and glycine metabolism in humans Adeva-Andany et al. (2018) Full text ↗ PubMed ↗
Glutathione as a skin whitening agent: Facts, myths, evidence and controversies Sonthalia et al. (2016) PubMed ↗
Glutamate uptake Danbolt (2001) Full text ↗ PubMed ↗

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