Depression
A common, serious mood disorder causing persistent low mood, loss of interest, and difficulty functioning. It is linked to dysregulated monoamine signalling (serotonin, norepinephrine, dopamine) and glutamate/GABA balance, and is highly treatable.
Functions
Hormones
Neurotransmitters
Books (16)
An Unquiet Mind
Cognitive Therapy and the Emotional Disorders
Cognitive Therapy of Depression
Cognitive-Behavioral Treatment of Borderline Personality Disorder
Darkness Visible: A Memoir of Madness
DBT Skills Training Manual, Second Edition
Feeling Good: The New Mood Therapy
Lost Connections: Uncovering the Real Causes of Depression
Reasons to Stay Alive
Skills Training Manual for Treating Borderline Personality Disorder
The depression workbook
The Feeling Good Handbook
The Noonday Demon: An Atlas of Depression
The Upward Spiral: Using Neuroscience to Reverse the Course of Depression
Touched with Fire
Undoing Depression
Podcasts
- All In The Mind
ABC RN's exploration of the mind, brain, and human behavior.
-
- Ten Percent Happier with Dan Harris | 5 minute podcast summaries
Dan Harris on meditation, the mind, and handling emotions.
- The One You Feed | Personal Growth, Emotional Resilience & Purpose
Practical wisdom for building better habits and mental health.
Research (174)
- Assessment of diverse deep brain stimulation targets uncovers a common neural pathway for instantaneous antidepressant effects in rats Liu et al. (2026) Full text ↗ PubMed ↗
- Clinical evaluation of adjunctive magnesium therapy in patients receiving antidepressants for depression-open label, nonrandomized clinical trial Siddique et al. (2026) PubMed ↗
- Medications for Opioid Use Disorder, Opioid Withdrawal, and Opioid Overdose: A Review Harris et al. (2026) Full text ↗ PubMed ↗
- From mother to infant: a case report exploring postpartum depression through a cross-cultural lens in Qatar Al-Mulla (2026) Full text ↗ PubMed ↗
- REM Rebound Effect Singh et al. (2026) PubMed ↗
- Adjunctive Lumateperone in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial Durgam et al. (2025) Full text ↗ PubMed ↗
- Nutritional co-therapy with vitamin D and L-theanine reduces unpredictable mild chronic stress (UCMS) in aged mice by restoring alpha-oscillations, dopamine levels and behavioral improvement Hussain et al. (2025) Full text ↗ PubMed ↗
- All roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants Freudenberg et al. (2025) Full text ↗ PubMed ↗
- Management of Antidepressant-Induced Sexual Dysfunction: A Literature Review Tran et al. (2025) Full text ↗ PubMed ↗
- Intermittent fasting produces antidepressant-like effects by modulating dopamine D1 receptors in the medial prefrontal cortex Piao et al. (2025) Full text ↗ PubMed ↗
- Multi-omic analyses of the development of obesity-related depression linked to the gut microbe Anaerotruncus colihominis and its metabolite glutamate Chang et al. (2025) Full text ↗ PubMed ↗
- Demystifying the New Dilemma of Brain Rot in the Digital Era: A Review Yousef et al. (2025) Full text ↗ PubMed ↗
- Effect of Saffron Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment of Depression and Anxiety: A Meta-analysis of Randomized Controlled Trials Shafiee et al. (2025) Full text ↗ PubMed ↗
- Obstructive Sleep Apnea Anderson et al. (2025) Full text ↗ PubMed ↗
- Antidepressive and anxiolytic effects of a combination of Saffron and Chamomile in rats and their relationship with serotonin using methods Ahmad et al. (2025) Full text ↗ PubMed ↗
Links
Recovery resources
Help for depression use and recovery. Not an endorsement or medical advice — see all recovery resources.
988 Suicide & Crisis Lifeline (US)
☎ 988A free, 24/7 US hotline (call or text 988) providing immediate support for anyone in suicidal crisis or emotional distress.
Crisis Text Line (text HOME to 741741)
☎ 741741Free, 24/7 crisis support by text message with a trained volunteer counselor (text HOME to 741741 in the US).
SAMHSA National Helpline (US)
A free, confidential, 24/7 US treatment-referral and information line for individuals and families facing substance use or mental health disorders.
- Emotional Health Anonymous (EHA)
A 12-step program supporting recovery from emotional and mental-health struggles.
Emotions Anonymous (EA)
A 12-step fellowship for people working toward emotional wellbeing amid anxiety, depression, and other difficulties.
Community
Log in to rate and share your notes.
No contributions yet.